Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28586012 | 0.93 | MAPK1 (0.53) | EPHX2MAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL3756652 | 0.93 | MAPK1 (0.53) | EPHX2MAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4270527 | 0.93 | MAPK1 (0.53) | EPHX2MAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL29117235 | 0.92 | ALDH1A1 (0.60) | EPHX2MAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL29117233 | 0.92 | ALDH1A1 (0.60) | EPHX2MAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL1437945 | 0.89 | EPHX2 (0.61) | EPHX2MAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4779124 | 0.86 | ALDH1A1 (0.54) | EPHX2MAPK1ALDH1A1L3MBTL1GAA | |
| SCHEMBL16992397 | 0.82 | MAPK1 (0.55) | EPHX2MAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4117275 | 0.79 | KDM5A (0.49) | EPHX2ALDH1A1L3MBTL1 | |
| SCHEMBL1624691 | 0.79 | KDM5A (0.52) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |