Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | APOL1 | O14791 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146145 | 1.00 | HTR2C (0.52) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL2146425 | 0.98 | HTR2C (0.51) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL2146434 | 0.98 | HTR2C (0.51) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL15421949 | 0.90 | SLC6A1 (0.49) | HTR2CSMN1; SMN2HSD17B10JAK1TSHR | |
| SCHEMBL15421898 | 0.89 | GNAI3 (0.49) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL28446460 | 0.89 | SLC6A1 (0.47) | HTR2CSMN1; SMN2HSD17B10JAK1TSHR | |
| Hydrochloric Acid SCHEMBL28439551 | 0.88 | GNAI3 (0.51) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL21640562 | 0.85 | SMN1; SMN2 (0.40) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL29516447 | 0.85 | HTR2C (0.51) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL4635091 | 0.83 | SMN1; SMN2 (0.47) | HTR2CSMN1; SMN2GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |