Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | LSS | P48449 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21767375 | 0.83 | NAMPT (0.37) | TAAR1NAMPTLIPGLIPCLSS | |
| SCHEMBL21767377 | 0.83 | NAMPT (0.37) | TAAR1NAMPTLIPGLIPCLSS | |
| SCHEMBL22835940 | 0.81 | LIPG (0.42) | TAAR1NAMPTLIPGLIPCDPP7 | |
| SCHEMBL16414502 | 0.81 | LIPG (0.42) | TAAR1NAMPTLIPGLIPCDPP7 | |
| SCHEMBL22835620 | 0.81 | LIPG (0.42) | TAAR1NAMPTLIPGLIPCDPP7 | |
| SCHEMBL28559049 | 0.81 | LMNA (0.35) | TAAR1NAMPTLIPGLIPCLSS | |
| SCHEMBL21767473 | 0.80 | NAMPT (0.33) | TAAR1NAMPTLIPGLIPCLSS | |
| SCHEMBL28334816 | 0.80 | LSS (0.37) | TAAR1NAMPTLIPGLIPCLSS | |
| SCHEMBL21767475 | 0.80 | NAMPT (0.33) | TAAR1NAMPTLIPGLIPCLSS | |
| SCHEMBL28334814 | 0.80 | LSS (0.37) | TAAR1NAMPTLIPGLIPCLSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |