Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.32 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146346 | 0.88 | HPGD (0.49) | HPGDSMN1; SMN2NOTUMALDH1A1TSHR | |
| SCHEMBL28214294 | 0.80 | DPP4 (0.34) | — | |
| SCHEMBL23779158 | 0.78 | GAA (0.37) | SMN1; SMN2ALDH1A1LMNAHSD17B10MAPK1 | |
| SCHEMBL26599493 | 0.74 | NOTUM (0.41) | SMN1; SMN2NOTUMALDH1A1CHRNB2CHRNA3 | |
| SCHEMBL28878334 | 0.74 | HPGD (0.54) | RECQLHPGDSMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL28210822 | 0.74 | HRH4 (0.30) | — | |
| SCHEMBL1609526 | 0.73 | EPHX2 (0.39) | ALDH1A1LMNAMAPK1EPHX2 | |
| SCHEMBL2895470 | 0.73 | DPP4 (0.31) | — | |
| SCHEMBL25341666 | 0.71 | — | — | |
| SCHEMBL6209477 | 0.71 | SMN1; SMN2 (0.49) | HPGDSMN1; SMN2ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |