Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146290 | 0.88 | RECQL (0.40) | HPGDALDH1A1SMN1; SMN2NOTUMTSHR | |
| SCHEMBL23779158 | 0.78 | GAA (0.37) | ALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL28310203 | 0.75 | HPGD (0.63) | HPGDALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL980149 | 0.74 | MLYCD (0.32) | HPGDALDH1A1TSHRKMT2A | |
| SCHEMBL28172922 | 0.74 | ALDH1A1 (0.38) | ALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL26599493 | 0.74 | NOTUM (0.41) | ALDH1A1SMN1; SMN2NOTUM | |
| SCHEMBL2146182 | 0.74 | EPHX2 (0.45) | ALDH1A1KMT2ALMNA | |
| SCHEMBL28214294 | 0.73 | DPP4 (0.34) | — | |
| SCHEMBL1609526 | 0.73 | EPHX2 (0.39) | ALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL2721518 | 0.72 | MLYCD (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |