⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11464823 | 0.97 | — | — | |
| SCHEMBL11382430 | 0.97 | CA1 (0.55) | — | |
| SCHEMBL2858061 | 0.79 | — | — | |
| SCHEMBL187410 | 0.76 | CA1 (0.55) | — | |
| SCHEMBL2442152 | 0.76 | — | — | |
| SCHEMBL1274411 | 0.74 | ALDH1A1 (0.59) | — | |
| Hydrochloric Acid SCHEMBL11848293 | 0.73 | CA1 (0.52) | — | |
| Methane SCHEMBL27649004 | 0.73 | CA1 (0.52) | — | |
| Pyrrolidine Dithiocarbamate SCHEMBL322100 | 0.71 | — | — | |
| SCHEMBL1276482 | 0.71 | CA1 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1980000537-A1 | PYRIMIDO(1,6-A)INDOLE DERIVATIVES | AMERICAN HOME PROD (US) | 1980-04-03 | — | — | WO | claimed |
| EP-0008950-A2 | Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-03-19 | — | — | EP | claimed |
| US-20120046276-A1 | Tuberculosis treatment using pleuromutilin derivatives | NABRIVA THERAPEUTICS AG (AT) | 2012-02-23 | — | — | US | disclosed |
| US-8088823-B2 | Tuberculosis treatment using pleuromutilin derivatives | NABRIVA THERAPEUTICS AG (AT) | 2012-01-03 | — | — | US | disclosed |
| EP-1501495-B1 | USE OF PLEUROMUTILINS FOR THE TREATMENT OF DISORDERS CAUSED BY HELICOBACTER PYLORI | NABRIVA THERAPEUTICS AG (AT) | 2010-09-08 | — | — | EP | disclosed |
| US-7790749-B2 | Use of pleuromutilins for the treatment of disorders caused by Helicobacter pylori | NABRIVA THERAPEUTICS AG (AT) | 2010-09-07 | — | — | US | disclosed |
| EP-1875903-A1 | TUBERCULOSIS TREATMENT USING PLEUROMUTILIN DERIVATIVES | Nabriva Therapeutics Forschungs GmbH (AT) | 2008-01-09 | — | — | EP | disclosed |
| US-20070270404-A1 | Tuberculosis treatment using pleuromutilin derivatives | NABRIVA THERAPEUTICS FORSCHUNGS GMBH (AT) | 2007-11-22 | — | — | US | disclosed |
| US-20050215637-A1 | Tuberculosis treatment | ASCHER GERD | 2005-09-29 | — | — | US | disclosed |
| US-20050131023-A1 | Use of pleuromutilins for the treatment of disorders caused by helicobacter pylori | HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) | 2005-06-16 | — | — | US | disclosed |
| EP-1501495-A1 | USE OF PLEUROMUTILINS FOR THE TREATMENT OF DISORDERS CAUSED BY HELICOBACTER PYLORI | Sandoz AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| US-4409224-A | Pyrimido[1,6-a]indole derivatives | AMERICAN HOME PRODUCTS CORP. (US) | 1983-10-11 | — | — | US | disclosed |
| US-4310590-A | BACTERICIDES, FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1982-01-12 | — | — | US | disclosed |
| US-4307234-A | Pyrimido[1,6-a]indole derivatives | AMERICAN HOME PRODUCTS CORP. (US) | 1981-12-22 | — | — | US | disclosed |
| EP-0031705-A1 | Substituted 3-isothiazolones, salts and metal salt complexes thereof, compositions containing them and their use for combating bacteria, algae and fungi | ROHM AND HAAS COMPANY (US) | 1981-07-08 | — | — | EP | disclosed |
| WO-1980000537-A1 | PYRIMIDO(1,6-A)INDOLE DERIVATIVES | AMERICAN HOME PROD (US) | 1980-04-03 | — | — | WO | disclosed |
| EP-0008950-A2 | Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-03-19 | — | — | EP | disclosed |
| US-4060542-A | 14-Desoxy-14 thiocyanato-acetoxy-mutilin | BIOCHEMIE GESELLSCHAFT M.B.H. (OE) | 1977-11-29 | — | — | US | disclosed |
| US-3979423-A | FEED ADDITIVES | BIOCHEMIE GESELLSCHAFT M.B.H. (OE) | 1976-09-07 | — | — | US | disclosed |
| US-3979423-A | FEED ADDITIVES | BIOCHEMIE GESELLSCHAFT M.B.H. (OE) | 1976-09-07 | — | — | US | disclosed |