SCHEMBL2146379

SCHEMBL2146379

CCOC(=O)C(NC(=O)c1cc(C)c(OC)c(C)c1)C(=O)OCC

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 10/20 0.60
TAS1R1 Q7RTX1 10/20 0.60
MAPK1 P28482 1/20 0.48
ALDH1A1 P00352 3/20 0.45
HPGD P15428 2/20 0.43
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14486846 0.83 TAS1R3 (0.57) TAS1R3TAS1R1MAPK1ALDH1A1KDM4E
SCHEMBL14798404 0.79 TAS1R3 (0.54) TAS1R3TAS1R1MAPK1ALDH1A1KDM4E
SCHEMBL5424180 0.77 TAS1R3 (0.61) TAS1R3TAS1R1ALDH1A1HPGDKDM4E
SCHEMBL13293378 0.76 TAS1R3 (0.52) TAS1R3TAS1R1MAPK1ALDH1A1KDM4E
SCHEMBL4205980 0.75 TAS1R3 (1.00) TAS1R3TAS1R1ALDH1A1KDM4EKMT2A
SCHEMBL4205978 0.75 TAS1R3 (1.00) TAS1R3TAS1R1ALDH1A1KDM4EKMT2A
SCHEMBL8985829 0.75 CA12 (0.58) TAS1R3TAS1R1ALDH1A1HPGDKDM4E
SCHEMBL1739421 0.75 ALDH1A1 (0.66) TAS1R3TAS1R1MAPK1ALDH1A1KDM4E
SCHEMBL5782189 0.74 KMT2A (0.54) TAS1R3TAS1R1ALDH1A1HPGDMEN1
SCHEMBL5784044 0.74 SMN1; SMN2 (0.55) ALDH1A1HPGDMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9321787-B2 Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring SANOFI (FR) 2016-04-26 US disclosed
US-9321787-B2 Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring SANOFI (FR) 2016-04-26 US disclosed
EP-2729471-B1 CARBOXYLIC ACID DERIVATIVES WITH AN OXAZOLO[5,4-D]PYRIMIDINE RING SANOFI SA (FR) 2015-05-06 EP disclosed
EP-2729471-B1 CARBOXYLIC ACID DERIVATIVES WITH AN OXAZOLO[5,4-D]PYRIMIDINE RING SANOFI SA (FR) 2015-05-06 EP disclosed
US-8846691-B2 Heterocyclic carboxylic acid derivatives having a 2,5,7-substituted oxazolopyrimidine ring SANOFI (FR) 2014-09-30 US disclosed
US-8748436-B2 Carboxylic acid derivatives having a 2,5,7-substituted oxazolopyrimidine ring SANOFI (FR) 2014-06-10 US disclosed
EP-2729471-A1 CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-D]PYRIDINE RING SANOFI (FR) 2014-05-14 EP disclosed
EP-2523958-B1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI SA (FR) 2013-12-25 EP disclosed
EP-2523959-B1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI SA (FR) 2013-11-27 EP disclosed
US-20130158051-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2013-06-20 US disclosed
US-20130079357-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2013-03-28 US disclosed
US-20130023544-A1 CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-d]PYRIMIDINE RING SANOFI (FR) 2013-01-24 US disclosed
US-20130023544-A1 CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-d]PYRIMIDINE RING SANOFI (FR) 2013-01-24 US disclosed
WO-2013004827-A1 CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-D]PYRIDINE RING SANOFI (FR) 2013-01-10 WO disclosed
EP-2523958-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2012-11-21 EP disclosed
EP-2523959-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2012-11-21 EP disclosed
WO-2011086077-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI-AVENTIS (FR) 2011-07-21 WO disclosed
WO-2011086078-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI-AVENTIS (FR) 2011-07-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130079357-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING DPYD, OXGR1, ALDH1A1 TAS1R3 2462/4885TAS1R1 1841/4885MAPK1 1499/4885
US-20130158051-A1 HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES HAVING A 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE RING OXGR1, DPYD, FGF2 TAS1R3 2452/4885TAS1R1 1804/4885MAPK1 1408/4885
US-20130023544-A1 CARBOXYLIC ACID DERIVATIVES HAVING AN OXAZOLO[5,4-d]PYRIMIDINE RING OXGR1, CXCR1, DPYD TAS1R3 2002/4885TAS1R1 1760/4885MAPK1 1646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.