Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146128 | 0.86 | GRIN1 (0.41) | GRIN1GRIN2BHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL2146132 | 0.79 | GAA (0.40) | GRIN1GRIN2BFKBP1AALDH1A1MAPT | |
| SCHEMBL28383178 | 0.77 | GRIN2B (0.58) | GRIN1GRIN2BRIPK1 | |
| SCHEMBL17633359 | 0.77 | GRIN2B (0.58) | GRIN1GRIN2BRIPK1 | |
| SCHEMBL17633278 | 0.77 | GRIN2B (0.58) | GRIN1GRIN2BRIPK1 | |
| SCHEMBL17633280 | 0.77 | GRIN2B (0.58) | GRIN1GRIN2BRIPK1 | |
| SCHEMBL2146215 | 0.75 | MEN1 (0.42) | ALDH1A1PPARGPPARA | |
| SCHEMBL27076325 | 0.75 | GRIN1 (0.36) | GRIN1GRIN2BHPGDRIPK1FKBP1A | |
| SCHEMBL27076326 | 0.75 | GRIN1 (0.36) | GRIN1GRIN2BHPGDRIPK1FKBP1A | |
| SCHEMBL27076333 | 0.75 | GRIN1 (0.36) | GRIN1GRIN2BHPGDRIPK1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |