Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CPS1 | P31327 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146384 | 0.86 | GRIN1 (0.39) | GRIN1GRIN2BALDH1A1MAPTHPGD | |
| SCHEMBL2146132 | 0.80 | GAA (0.40) | GRIN1GRIN2BALDH1A1LMNAMEN1 | |
| SCHEMBL2146215 | 0.78 | MEN1 (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL27900160 | 0.76 | MGLL (0.40) | NPC1RAB9A | |
| SCHEMBL12497264 | 0.74 | TRPV4 (0.44) | SCN9AHPGD | |
| SCHEMBL16801543 | 0.73 | MKNK2 (0.47) | MKNK2GPR6 | |
| SCHEMBL16801870 | 0.73 | MKNK2 (0.47) | MKNK2GPR6 | |
| SCHEMBL18982966 | 0.73 | MKNK2 (0.47) | MKNK2GPR6 | |
| SCHEMBL4199136 | 0.73 | ALDH1A1 (0.41) | ALDH1A1LMNATDP1MEN1KMT2A | |
| SCHEMBL19006122 | 0.70 | MKNK2 (0.45) | MKNK2GPR6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |