⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146386 | 1.00 | — | — | |
| SCHEMBL2288702 | 0.89 | USP14 (0.32) | — | |
| SCHEMBL2288699 | 0.89 | USP14 (0.32) | — | |
| SCHEMBL2313264 | 0.75 | KDM4E (0.35) | — | |
| SCHEMBL2146466 | 0.74 | ERN1 (0.37) | — | |
| SCHEMBL2146461 | 0.74 | ERN1 (0.37) | — | |
| SCHEMBL2146478 | 0.73 | MAPT (0.34) | — | |
| SCHEMBL2146484 | 0.73 | MAPT (0.34) | — | |
| SCHEMBL2146817 | 0.69 | LMNA (0.35) | — | |
| SCHEMBL2146820 | 0.69 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201555-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-08-18 | — | — | US | claimed |
| EP-2346824-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-07-27 | — | — | EP | claimed |
| WO-2010031852-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2010-03-25 | — | — | WO | claimed |
| US-20110201555-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-08-18 | — | — | US | disclosed |