Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25691077 | 0.85 | SLC16A3 (0.46) | KMT2AKDM4ESIRT6ALDH1A1MAPT | |
| SCHEMBL21464361 | 0.84 | KDM4E (0.45) | KMT2AKDM4ESIRT6ALDH1A1MAPT | |
| SCHEMBL29966594 | 0.84 | KDM4E (0.45) | KMT2AKDM4ESIRT6ALDH1A1MAPT | |
| SCHEMBL30612711 | 0.84 | MAPT (0.49) | KMT2ACTSSCTSKALDH1A1MAPT | |
| SCHEMBL20235026 | 0.84 | MAPT (0.49) | KMT2ACTSSCTSKALDH1A1MAPT | |
| SCHEMBL30906240 | 0.80 | MAPK3 (0.49) | KMT2ACTSSCTSKALDH1A1MAPT | |
| SCHEMBL20213879 | 0.79 | SIRT6 (0.44) | KMT2AKDM4ESIRT6CTSLCTSB | |
| SCHEMBL21876910 | 0.79 | CHRM4 (0.47) | KMT2AKDM4ESIRT6ALDH1A1MAPT | |
| SCHEMBL13152897 | 0.79 | LMNA (0.44) | KDM4ECTSLCTSBCTSSCTSK | |
| SCHEMBL24696583 | 0.79 | KDM4E (0.44) | KMT2AKDM4ESIRT6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774772-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas Operations, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019199816-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |