Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25040953 | 1.00 | CHRNB2 (0.45) | CHRNB2CHRNA4CA1CA2KDM4E | |
| SCHEMBL16488064 | 0.89 | CTSK (0.43) | SLC6A2 | |
| SCHEMBL12193497 | 0.89 | CTSK (0.43) | SLC6A2 | |
| SCHEMBL24789850 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL2729991 | 0.83 | CA1 (0.63) | CA1CA2 | |
| SCHEMBL12440607 | 0.83 | CA1 (0.63) | CA1CA2 | |
| SCHEMBL5007614 | 0.83 | CA1 (0.63) | CA1CA2 | |
| SCHEMBL14645713 | 0.81 | KDM4E (0.47) | CHRNB2CHRNA4CA1CA2KDM4E | |
| SCHEMBL10211551 | 0.81 | CA1 (0.57) | CHRNB2CHRNA4CA1CA2KDM4E | |
| SCHEMBL10061696 | 0.81 | CA1 (0.57) | CHRNB2CHRNA4CA1CA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774760-A1 | PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER | Eisai R&D Management Co., Ltd. (JP) | 2021-02-17 | — | — | EP | claimed |
| WO-2019200100-A1 | PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER | COOK ANDREW (US) | 2019-10-17 | — | — | WO | claimed |
| EP-4658653-A1 | IMIDAZO[1,2-D][1,2,4]TRIAZINES AS NLRP3 INHIBITORS | Janssen Pharmaceutica NV (BE) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024160692-A1 | IMIDAZO[1,2-D][1,2,4]TRIAZINES AS NLRP3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-08-08 | — | — | WO | disclosed |
| EP-3774760-A1 | PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER | Eisai R&D Management Co., Ltd. (JP) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019200100-A1 | PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER | COOK ANDREW (US) | 2019-10-17 | — | — | WO | disclosed |