Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21464809 | 1.00 | CYP2D6 (0.36) | CYP2D6CYP3A4CYP2C19CASP1ATM | |
| SCHEMBL21464901 | 0.88 | CYP2D6 (0.36) | CYP2D6CYP3A4CYP2C19CASP1ATM | |
| SCHEMBL21464902 | 0.88 | CYP2D6 (0.36) | CYP2D6CYP3A4CYP2C19CASP1ATM | |
| SCHEMBL22459535 | 0.84 | TP53 (0.33) | TSHR | |
| SCHEMBL29659302 | 0.82 | CYP2D6 (0.43) | CYP2D6CYP3A4CYP2C19CASP1ATM | |
| SCHEMBL21478373 | 0.65 | SF3B3 (0.33) | — | |
| SCHEMBL21428432 | 0.63 | LMNA (0.47) | LMNAHTT | |
| SCHEMBL30743828 | 0.62 | TSHR (0.40) | CYP2D6CYP3A4CYP2C19CASP1MEN1 | |
| SCHEMBL21428419 | 0.62 | LMNA (0.50) | LMNAHTT | |
| SCHEMBL23404581 | 0.61 | CYP2D6 (0.33) | CYP2D6CYP3A4CYP2C19CASP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774760-A1 | PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER | Eisai R&D Management Co., Ltd. (JP) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019200100-A1 | PLADIENOLIDE DERIVATIVES AS SPLICEOSOME TARGETING AGENTS FOR TREATING CANCER | COOK ANDREW (US) | 2019-10-17 | — | — | WO | disclosed |