Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21462436 | 0.94 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL5872547 | 0.80 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL5872540 | 0.74 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL5236635 | 0.73 | PDCD1 (0.44) | KMT2AMEN1RAB9ACD274HDAC4 | |
| SCHEMBL9057181 | 0.73 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL7703141 | 0.72 | DPP4 (0.39) | KMT2ACD274BACE1ALDH1A1 | |
| SCHEMBL21408619 | 0.72 | DPP4 (0.59) | KMT2ARAB9ACD274BACE1ALDH1A1 | |
| SCHEMBL5685480 | 0.72 | DPP4 (0.39) | KMT2ARAB9ACD274BACE1LMNA | |
| SCHEMBL6670308 | 0.72 | DPP4 (0.39) | KMT2ACD274BACE1ALDH1A1 | |
| SCHEMBL5611030 | 0.72 | SETDB1 (0.40) | KMT2ACD274HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021064188-A1 | COMBINATION COMPRISING HDAC INHIBITOR, CTLA-4 INHIBITOR AND A PD-1 INHIBITOR OR PD-L1 INHIBITOR FOR CANCER TREATMENT | 4SC AG (DE) | 2021-04-08 | — | — | WO | disclosed |
| WO-2019200238-A1 | COMBINATIONS INCLUDING A CPG-C TYPE OLIGONUCLEOTIDE AND A HISTONE DEACETYLASE INHIBITOR FOR TREATING CANCER | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2019-10-17 | — | — | WO | disclosed |