Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETDB1 | Q15047 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12462407 | 0.81 | SETDB1 (0.49) | SETDB1BRD4POLBKDM4ETSHR | |
| SCHEMBL5685480 | 0.77 | DPP4 (0.39) | KDM4EPTGS2KMT2APDCD1CD274 | |
| SCHEMBL1479870 | 0.75 | LMNA (0.42) | SETDB1POLBKDM4ETSHRRECQL | |
| SCHEMBL21408485 | 0.74 | CKS1B (0.46) | PTGS2KMT2ACYP19A1KEAP1 | |
| SCHEMBL5236635 | 0.72 | PDCD1 (0.44) | KDM4ETSHRKMT2APDCD1CD274 | |
| SCHEMBL5611086 | 0.72 | PTGS2 (0.40) | SETDB1BRD4POLBKDM4ETSHR | |
| SCHEMBL21465705 | 0.72 | SLC6A2 (0.49) | KDM4EKMT2ACD274HTT | |
| SCHEMBL21408483 | 0.71 | ADRB2 (0.49) | KDM4EKMT2APDCD1CD274HTT | |
| SCHEMBL8838466 | 0.71 | DPP4 (0.37) | KDM4EKMT2APDCD1CD274HPGD | |
| SCHEMBL5240256 | 0.71 | PTGS2 (0.46) | KDM4EPTGS2KMT2AHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861365-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | Nycomed GmbH (DE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097474-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | NYCOMED GMBH (DE) | 2006-09-21 | — | — | WO | disclosed |