Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | NPY4R | P50391 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146784 | 1.00 | TRPA1 (0.38) | TRPA1SLC6A2NPY1RNPY2RNPY4R | |
| SCHEMBL2146780 | 1.00 | TRPA1 (0.38) | TRPA1SLC6A2NPY1RNPY2RNPY4R | |
| SCHEMBL11244532 | 0.85 | HTR2B (0.42) | TRPA1SLC6A2NPY1RNPY2RNPY4R | |
| SCHEMBL11244526 | 0.85 | HTR2B (0.42) | TRPA1SLC6A2NPY1RNPY2RNPY4R | |
| SCHEMBL11236259 | 0.85 | HTR2B (0.42) | TRPA1SLC6A2NPY1RNPY2RNPY4R | |
| SCHEMBL11236271 | 0.85 | HTR2B (0.42) | TRPA1SLC6A2NPY1RNPY2RNPY4R | |
| SCHEMBL11236266 | 0.85 | HTR2B (0.42) | TRPA1SLC6A2NPY1RNPY2RNPY4R | |
| SCHEMBL10839532 | 0.84 | MEN1 (0.37) | SLC6A2NPY1RNPY2RNPY4RNPY5R | |
| SCHEMBL10839525 | 0.84 | MEN1 (0.37) | SLC6A2NPY1RNPY2RNPY4RNPY5R | |
| SCHEMBL10839528 | 0.84 | MEN1 (0.37) | SLC6A2NPY1RNPY2RNPY4RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |