Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | GRK2 | P25098 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | NPY4R | P50391 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11236259 | 1.00 | HTR2B (0.42) | HTR2BHTR2CGRK2SLC6A2SLC6A4 | |
| SCHEMBL11236266 | 1.00 | HTR2B (0.42) | HTR2BHTR2CGRK2SLC6A2SLC6A4 | |
| SCHEMBL11244526 | 1.00 | HTR2B (0.42) | HTR2BHTR2CGRK2SLC6A2SLC6A4 | |
| SCHEMBL11236271 | 1.00 | HTR2B (0.42) | HTR2BHTR2CGRK2SLC6A2SLC6A4 | |
| SCHEMBL11243039 | 0.85 | NPY1R (0.40) | GRK2SLC6A2SLC6A4SLC6A3NPY1R | |
| SCHEMBL11243046 | 0.85 | NPY1R (0.40) | GRK2SLC6A2SLC6A4SLC6A3NPY1R | |
| SCHEMBL11243041 | 0.85 | NPY1R (0.40) | GRK2SLC6A2SLC6A4SLC6A3NPY1R | |
| SCHEMBL2146784 | 0.85 | TRPA1 (0.38) | GRK2SLC6A2SLC6A4SLC6A3NPY1R | |
| SCHEMBL2146780 | 0.85 | TRPA1 (0.38) | GRK2SLC6A2SLC6A4SLC6A3NPY1R | |
| SCHEMBL2146789 | 0.85 | TRPA1 (0.38) | GRK2SLC6A2SLC6A4SLC6A3NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |