Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21470053 | 0.86 | KMT2A (0.50) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL21470146 | 0.84 | KMT2A (0.49) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL23799441 | 0.84 | KMT2A (0.51) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL29217576 | 0.82 | FFAR1 (0.50) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL8517366 | 0.80 | PRSS1 (0.65) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| Bromide SCHEMBL11186851 | 0.79 | PRSS1 (0.63) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9183990 | 0.79 | PRSS1 (0.63) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11187297 | 0.79 | PRSS1 (0.63) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL21470123 | 0.79 | PRSS1 (0.46) | KMT2APRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL27659306 | 0.78 | PRSS1 (0.62) | KMT2APRSS1PRSS2PRSS3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200367-A9 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-12-19 | — | — | WO | disclosed |
| WO-2019200367-A1 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-10-17 | — | — | WO | disclosed |