Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21470050 | 0.88 | PRSS1 (0.47) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL24103833 | 0.86 | PRSS1 (0.46) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL23783472 | 0.86 | KMT2A (0.45) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL27105868 | 0.85 | KMT2A (0.48) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL23800867 | 0.82 | KMT2A (0.43) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL29990493 | 0.81 | PRSS1 (0.62) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL23783466 | 0.81 | KMT2A (0.42) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL27105866 | 0.81 | KMT2A (0.43) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL21470124 | 0.79 | KMT2A (0.49) | PRSS1PRSS2PRSS3KMT2AMEN1 | |
| SCHEMBL16342206 | 0.78 | KMT2A (0.43) | PRSS1PRSS2PRSS3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210386861-A1 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-12-16 | — | — | US | disclosed |
| WO-2019200367-A9 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-12-19 | — | — | WO | disclosed |
| WO-2019200367-A1 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210386861-A1 | BRUSH PRODRUGS AND USES THEREOF | ABCB11, SI, ABCB1 | PRSS1 413/4885PRSS2 297/4885PRSS3 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.