Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.40 |
| ▸ | PPIB | P23284 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | PPIG | Q13427 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993946 | 0.86 | CYP1A2 (0.46) | CYP1A2LMNACYP3A4MAOASMN1; SMN2 | |
| SCHEMBL8993953 | 0.85 | CYP1A2 (0.45) | CYP1A2LMNACYP3A4MAOASMN1; SMN2 | |
| SCHEMBL8993978 | 0.83 | CYP1A2 (0.44) | CYP1A2LMNACYP3A4MAOASMN1; SMN2 | |
| SCHEMBL6287830 | 0.75 | APP (0.46) | LMNACYP3A4MAOAPHLPP2CYP2D6 | |
| SCHEMBL25567758 | 0.75 | CYP4F2 (0.51) | CYP1A2LMNACYP3A4MAOAPPIB | |
| SCHEMBL26775803 | 0.75 | TDP1 (0.42) | CYP1A2CYP3A4MAOAPHLPP2CYP2D6 | |
| SCHEMBL30997589 | 0.74 | DNM1 (0.51) | CYP1A2SMN1; SMN2KDM4EALDH1A1LTA4H | |
| SCHEMBL14570550 | 0.74 | SMN1; SMN2 (0.51) | CYP1A2CYP3A4SMN1; SMN2CYP2D6ALDH1A1 | |
| SCHEMBL31123215 | 0.73 | TDP1 (0.41) | CYP3A4PHLPP2TSHRALDH1A1HDAC3 | |
| SCHEMBL13700876 | 0.73 | MAPT (0.44) | CYP1A2LMNACYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002318-A1 | HETEROCYCLIC COMPOUND AS SYK INHIBITOR AND/OR SYK-HDAC DUAL INHIBITOR | HANGZHOU INNOGATE PHARMA CO., LTD. (CN) | 2022-01-06 | — | — | US | disclosed |
| US-11142535-B2 | Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor | HANGZHOU INNOGATE PHARMA CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
| EP-3553065-A1 | HETEROCYCLIC COMPOUND AS SYK INHIBITOR AND/OR SYK-HDAC DUAL INHIBITOR | Hangzhou Innogate Pharma Co., Ltd. (CN) | 2019-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11142535-B2 | Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor | SYK, HDAC1, HDAC2 | CYP1A2 2372/4885LMNA 4459/4885CYP3A4 1605/4885 |
| US-20220002318-A1 | HETEROCYCLIC COMPOUND AS SYK INHIBITOR AND/OR SYK-HDAC DUAL INHIBITOR | SYK, HDAC1, HDAC2 | CYP1A2 2372/4885LMNA 4459/4885CYP3A4 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.