SCHEMBL21472049

SCHEMBL21472049

Cc1cnc(N2CC3(CCOCC3)C2)c(C(=O)Nc2ccc(C(=O)N3CCc4cc(C(=O)c5cc(C(F)(F)F)nn5COCC[Si](C)(C)C)sc4-c4ccc(F)cc43)cc2)c1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 4/20 0.34
AVPR1A P37288 1/20 0.32
RAF1 P04049 13/20 0.31
BRAF P15056 13/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21471607 0.88 AVPR2 (0.35) AVPR2AVPR1A
SCHEMBL21471778 0.86 AVPR2 (0.34) AVPR2AVPR1A
SCHEMBL21471677 0.86 AVPR2 (0.40) AVPR2AVPR1ARAF1BRAF
SCHEMBL21471789 0.85 AVPR2 (0.33) AVPR2
SCHEMBL21471748 0.84 AVPR2 (0.38) AVPR2AVPR1ARAF1BRAF
SCHEMBL21471793 0.84 AVPR2 (0.40) AVPR2AVPR1A
SCHEMBL20620181 0.84 AVPR2 (0.41) AVPR2AVPR1ARAF1BRAF
SCHEMBL20619508 0.84 AVPR2 (0.41) AVPR2AVPR1A
SCHEMBL20619707 0.84 AVPR2 (0.42) AVPR2AVPR1A
SCHEMBL21471998 0.83 AVPR2 (0.40) AVPR2AVPR1ARAF1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10975094-B2 Heterocyclic compounds as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2021-04-13 US disclosed
US-20190315766-A1 HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. 2019-10-17 US disclosed
WO-2019199908-A1 HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2019-10-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10975094-B2 Heterocyclic compounds as RSV inhibitors SIRT1, FURIN, SIRT5 AVPR2 969/4885AVPR1A 1354/4885RAF1 2748/4885
US-20190315766-A1 HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS SIRT1, FURIN, SIRT5 AVPR2 969/4885AVPR1A 1354/4885RAF1 2748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.