Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.75 |
| ▸ | PDE2A | O00408 | 2/20 | 0.52 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30544977 | 0.87 | MMP9 (0.69) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL4575928 | 0.86 | MMP9 (0.73) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL6627298 | 0.84 | MMP9 (0.66) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL30796069 | 0.84 | MMP9 (0.66) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL14986294 | 0.83 | MMP9 (0.69) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL7734521 | 0.83 | MMP9 (0.69) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL12121924 | 0.83 | MMP9 (0.64) | MMP9PDE2AMEN1KMT2AHPGDS | |
| SCHEMBL9686076 | 0.81 | MMP9 (0.75) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL1321496 | 0.81 | MMP9 (0.66) | MMP9PDE2AUGT2B7MEN1KMT2A | |
| SCHEMBL9002961 | 0.80 | ALDH1A1 (0.68) | MMP9HCRTR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280701-B1 | A METHOD OF CHIRAL RESOLUTION OF THE KEY INTERMEDIATE OF THE SYNTHESIS OF APREMILAST AND ITS USE FOR THE PREPARATION OF PURE APREMILAST | ZENTIVA KS (CZ) | 2019-10-16 | — | — | EP | disclosed |