⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21473361 | 0.83 | ACE (0.31) | — | |
| SCHEMBL18610399 | 0.82 | CHRM2 (0.30) | — | |
| SCHEMBL17634453 | 0.79 | MGLL (0.32) | — | |
| SCHEMBL917047 | 0.79 | MGLL (0.32) | — | |
| SCHEMBL18513677 | 0.78 | CYP1A2 (0.33) | — | |
| SCHEMBL24201250 | 0.76 | CHRM2 (0.30) | — | |
| SCHEMBL18946973 | 0.74 | CHRM2 (0.32) | — | |
| SCHEMBL14450839 | 0.73 | ACE (0.32) | — | |
| SCHEMBL18812363 | 0.73 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL27373440 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738066-B2 | Prodrugs of glutamine analogs | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190315784-A1 | PRODRUGS OF GLUTAMINE ANALOGS | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C), AS COLLATERAL AGENT | 2019-10-17 | — | — | US | disclosed |