Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 4/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.34 |
| ▸ | PRKCG | P05129 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.34 |
| ▸ | PRKCH | P24723 | 2/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.34 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | PHKA2 | P46019 | 1/20 | 0.34 |
| ▸ | PHKA1 | P46020 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | PHKG1 | Q16816 | 1/20 | 0.34 |
| ▸ | PHKB | Q93100 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24629497 | 0.81 | BRD4 (0.60) | BRD4DDB1CRBN | |
| SCHEMBL21484158 | 0.79 | PRKCB (0.34) | PRKCBPRKD3PRKCGPRKCAPRKCH | |
| SCHEMBL12424595 | 0.79 | BRD4 (0.47) | BRD4HTR5ABRD2MAPK1OPRL1 | |
| SCHEMBL23132786 | 0.79 | BRD4 (0.47) | BRD4HTR5ABRD2MAPK1OPRL1 | |
| SCHEMBL21486490 | 0.77 | MAPT (0.41) | BRD4PRKCBPRKD3PRKCGPRKCA | |
| SCHEMBL16095176 | 0.77 | BRD4 (0.46) | BRD4HTR5ABRD2MAPK1OPRL1 | |
| SCHEMBL21568500 | 0.77 | NCF1 (0.48) | BRD4HTR5APRKCBPRKD3PRKCG | |
| SCHEMBL4373597 | 0.77 | BRD4 (0.66) | BRD4HTR5AMEN1KMT2ABRD2 | |
| SCHEMBL23103442 | 0.76 | BRD4 (0.46) | BRD4HTR5ABRD2OPRL1CHRM2 | |
| SCHEMBL24493463 | 0.76 | BRD4 (0.46) | BRD4HTR5ABRD2OPRL1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200202-A1 | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) | MORPHIC THERAPEUTIC, INC. (US) | 2019-10-17 | — | — | WO | disclosed |