Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 8/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 8/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 7/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484165 | 0.92 | PTGS2 (0.37) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 | |
| SCHEMBL21476004 | 0.80 | PTGS2 (0.37) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 | |
| SCHEMBL21476023 | 0.78 | PTGS2 (0.35) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 | |
| SCHEMBL22757290 | 0.71 | CREBBP (0.33) | BMPR1AACVRL1ACVR1BMPR1BHSD11B1 | |
| SCHEMBL15807129 | 0.70 | PTGS2 (0.42) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 | |
| SCHEMBL1106463 | 0.69 | PTGS2 (0.41) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 | |
| SCHEMBL21476019 | 0.67 | SIGMAR1 (0.40) | — | |
| SCHEMBL21476011 | 0.67 | AVPR1B (0.39) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 | |
| SCHEMBL1106511 | 0.66 | HRH3 (0.41) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 | |
| SCHEMBL27256766 | 0.65 | PTGS2 (0.38) | PTGS2PTGDR2BMPR1AACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200202-A1 | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) | MORPHIC THERAPEUTIC, INC. (US) | 2019-10-17 | — | — | WO | disclosed |