Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.47 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.47 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21476082 | 0.86 | UTS2R (0.46) | KEAP1NFE2L2UTS2RPOLBSMN1; SMN2 | |
| SCHEMBL6857598 | 0.83 | KEAP1 (0.59) | KEAP1NFE2L2CYP26A1ITGB3ITGA2B | |
| SCHEMBL15654637 | 0.79 | CYP26A1 (0.58) | KEAP1NFE2L2CYP26A1POLBSMN1; SMN2 | |
| SCHEMBL7362926 | 0.77 | KEAP1 (0.53) | KEAP1NFE2L2CYP26A1ITGB3ITGA2B | |
| SCHEMBL14408235 | 0.75 | CYP26A1 (0.54) | KEAP1NFE2L2CYP26A1POLBSMN1; SMN2 | |
| SCHEMBL15787346 | 0.75 | CYP26A1 (0.54) | KEAP1NFE2L2CYP26A1POLBSMN1; SMN2 | |
| SCHEMBL15787300 | 0.75 | CYP26A1 (0.54) | KEAP1NFE2L2CYP26A1POLBSMN1; SMN2 | |
| SCHEMBL21475910 | 0.73 | P2RX7 (0.38) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL8453630 | 0.73 | MME (0.51) | KEAP1NFE2L2CYP26A1POLBALDH1A1 | |
| SCHEMBL9829245 | 0.73 | SMN1; SMN2 (0.60) | ITGB3ITGA2BPOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200202-A1 | ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7) | MORPHIC THERAPEUTIC, INC. (US) | 2019-10-17 | — | — | WO | disclosed |