Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 1.00 |
| ▸ | RECQL | P46063 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 2/20 | 0.74 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.74 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | BCL2 | P10415 | 4/20 | 0.55 |
| ▸ | BAX | Q07812 | 4/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21477024 | 0.85 | MEN1 (1.00) | MEN1KMT2AMAPTTDP1GAA | |
| SCHEMBL29457691 | 0.77 | BCL2 (0.70) | MEN1KMT2AMAPTTDP1GAA | |
| SCHEMBL22692440 | 0.74 | MAPT (0.59) | MEN1KMT2AMAPTTDP1GAA | |
| SCHEMBL18069566 | 0.72 | BCL2 (0.63) | MEN1KMT2AMAPTTDP1GAA | |
| SCHEMBL28911461 | 0.71 | BCL2 (1.00) | BCL2BAXBCL2L1 | |
| Edaravone SCHEMBL4704 | 0.71 | KMT2A (1.00) | MEN1KMT2AMAPTTDP1GAA | |
| Edaravone SCHEMBL27972444 | 0.71 | KMT2A (1.00) | MEN1KMT2AMAPTTDP1GAA | |
| SCHEMBL22692432 | 0.70 | MEN1 (0.55) | MEN1KMT2AMAPTTDP1GAA | |
| SCHEMBL16273413 | 0.70 | MEN1 (0.55) | MEN1KMT2AMAPTTDP1GAA | |
| Edaravone SCHEMBL29109888 | 0.70 | KMT2A (0.90) | MEN1KMT2AMAPTTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315730-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | DANA-FARBER CANCER INSTITUTE, INC. | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315730-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | BAX, BAD, CASP3 | MEN1 4314/4885KMT2A 4718/4885MAPT 3506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.