Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 11/20 | 0.42 |
| ▸ | MAOB | P27338 | 11/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21464452 | 0.79 | CRBN (0.39) | MAOAMAOB | |
| SCHEMBL21480831 | 0.79 | MAOA (0.48) | MAOAMAOBDRD2HTR2ADRD4 | |
| SCHEMBL21477121 | 0.76 | AR (0.53) | — | |
| SCHEMBL30253629 | 0.76 | AR (0.53) | — | |
| SCHEMBL21957568 | 0.76 | AR (0.53) | — | |
| SCHEMBL21464478 | 0.74 | CRBN (0.41) | MAOAMAOB | |
| SCHEMBL20463182 | 0.71 | HRH3 (0.44) | MAOAMAOBDRD2 | |
| SCHEMBL21477175 | 0.70 | MAOA (0.40) | MAOAMAOBDRD2HTR2ADRD4 | |
| SCHEMBL24735576 | 0.69 | LRRK2 (0.51) | MAOAMAOBDRD2HTR2ADRD4 | |
| SCHEMBL24735128 | 0.69 | LRRK2 (0.51) | MAOAMAOBDRD2HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019199816-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |