Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.96 |
| ▸ | NPC1 | O15118 | 10/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.96 |
| ▸ | RAB9A | P51151 | 8/20 | 0.96 |
| ▸ | TP53 | P04637 | 8/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.96 |
| ▸ | HPGD | P15428 | 7/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.96 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.96 |
| ▸ | PKM | P14618 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592611 | 0.98 | HSD17B10 (1.00) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL12075241 | 0.88 | HSD17B10 (0.81) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL26540303 | 0.82 | KDM4E (0.71) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL824375 | 0.82 | NPC1 (0.69) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL29531707 | 0.82 | NPC1 (0.69) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL23079705 | 0.81 | NPC1 (0.69) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL13067549 | 0.81 | NPC1 (0.69) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL23079675 | 0.81 | NPC1 (0.69) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| Dibenzoylmethane SCHEMBL16212240 | 0.81 | RAB9A (0.68) | HSD17B10NPC1KDM4ERAB9ATP53 | |
| SCHEMBL15597544 | 0.80 | HSD17B10 (0.81) | HSD17B10NPC1KDM4ERAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526129-B1 | ETHYLENE POLYMERISATION PROCESS | SAUDI BASIC IND CORP (SABIC) (SA) | 2017-09-27 | — | — | EP | disclosed |
| WO-2011088990-A1 | ETHYLENE POLYMERISATION | SAUDI BASIC INDUSTRIES CORPORATION (SABIC) (SA) | 2011-07-28 | — | — | WO | disclosed |