Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.92 |
| ▸ | RAB9A | P51151 | 9/20 | 0.92 |
| ▸ | GAA | P10253 | 2/20 | 0.92 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.76 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.76 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.69 |
| ▸ | TP53 | P04637 | 4/20 | 0.69 |
| ▸ | PKM | P14618 | 3/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | LDHA | P00338 | 1/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 9/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | GFER | P55789 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2147086 | 0.96 | NPC1 (0.92) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL105095 | 0.96 | NPC1 (1.00) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| Benzene SCHEMBL28005151 | 0.96 | NPC1 (1.00) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| Hydrogen Sulfide SCHEMBL28075074 | 0.94 | NPC1 (0.96) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL4775610 | 0.94 | NPC1 (0.96) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL27926515 | 0.94 | NPC1 (0.96) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL2147022 | 0.94 | NPC1 (0.96) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL467859 | 0.94 | NPC1 (0.96) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| Potassium SCHEMBL4891434 | 0.94 | NPC1 (0.96) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL16416275 | 0.94 | NPC1 (0.96) | NPC1RAB9AGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088990-A1 | ETHYLENE POLYMERISATION | SAUDI BASIC INDUSTRIES CORPORATION (SABIC) (SA) | 2011-07-28 | — | — | WO | disclosed |