Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CASK | O14936 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.40 |
| ▸ | CDK14 | O94921 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | MAK | P20794 | 1/20 | 0.40 |
| ▸ | CDK11B | P21127 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21506248 | 0.88 | PAK1 (0.43) | PAK1CDK2CCNA1P2RX7HPGD | |
| SCHEMBL21481904 | 0.81 | P2RX7 (0.46) | P2RX7HPGDDGAT1CDK5CCNT1 | |
| SCHEMBL24991888 | 0.81 | P2RX7 (0.46) | P2RX7HPGDDGAT1CDK5CCNT1 | |
| SCHEMBL23185459 | 0.79 | PLK4 (0.50) | PAK1CDK2CCNA1P2RX7DGAT1 | |
| SCHEMBL21481807 | 0.78 | CRHR1 (0.41) | PAK1CRHR1 | |
| SCHEMBL21481921 | 0.76 | CD38 (0.39) | PAK1CDK2CCNA1DGAT1CCNA2 | |
| SCHEMBL21506745 | 0.76 | TNF (0.38) | PAK1CDK2CCNA1CDK4CDK5 | |
| SCHEMBL22927040 | 0.76 | FSCN1 (0.36) | CDK5CLK4DYRK1BRAB9ANPC1 | |
| SCHEMBL16382713 | 0.74 | CSNK2A2 (0.41) | CDK5CLK4DYRK1B | |
| SCHEMBL21506720 | 0.71 | DRD4 (0.42) | P2RX7CRHR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968201-B2 | Bicyclic carboxamides and methods of use thereof | TEMPEST THERAPEUTICS, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20190315712-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | TEMPEST THERAPEUTICS, INC. | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968201-B2 | Bicyclic carboxamides and methods of use thereof | PTGER4, PTGER2, CNR2 | PAK1 1555/4885CDK2 394/4885CCNA1 2465/4885 |
| US-20190315712-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | PTGER4, PTGER2, CNR2 | PAK1 1555/4885CDK2 394/4885CCNA1 2465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.