Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23334495 | 1.00 | POLB (0.57) | POLBHSD17B10PKMKMT2AMEN1 | |
| SCHEMBL1703120 | 0.85 | L3MBTL3 (0.53) | KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL3632935 | 0.84 | L3MBTL3 (0.51) | POLBHSD17B10ALDH1A1 | |
| SCHEMBL20762032 | 0.83 | L3MBTL3 (0.51) | KDM4E | |
| SCHEMBL8178427 | 0.82 | SHMT2 (0.50) | POLBHSD17B10PKMKMT2AMEN1 | |
| SCHEMBL23689560 | 0.82 | IRAK4 (0.44) | POLBHSD17B10MGLLKCNH2HRH3 | |
| SCHEMBL25220881 | 0.82 | IRAK4 (0.44) | POLBHSD17B10MGLLKCNH2HRH3 | |
| SCHEMBL4383127 | 0.81 | EPHX1 (0.57) | POLBHSD17B10KMT2AMEN1MGLL | |
| SCHEMBL20074966 | 0.79 | HRH3 (0.40) | POLBHSD17B10KCNH2HRH3 | |
| SCHEMBL1971010 | 0.79 | EPHX1 (0.55) | POLBHSD17B10KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019199667-A2 | CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE | KEANEY GREGG F (US) | 2019-10-17 | — | — | WO | disclosed |