Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 16/20 | 0.51 |
| ▸ | CCND1 | P24385 | 15/20 | 0.51 |
| ▸ | CCND3 | P30281 | 9/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.51 |
| ▸ | CCND2 | P30279 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23488908 | 0.81 | CDK4 (0.61) | MEN1ALDH1A1KMT2ACDK4CCND1 | |
| SCHEMBL21460208 | 0.79 | CDK4 (0.59) | MEN1ALDH1A1KMT2ACDK4CCND1 | |
| SCHEMBL23846293 | 0.78 | CDK4 (0.56) | CDK4CCND1CCND3CDK6CCND2 | |
| SCHEMBL31018774 | 0.78 | CDK4 (0.60) | CDK4CCND1CCND3CDK6CCND2 | |
| SCHEMBL29333468 | 0.74 | CDK4 (0.63) | CDK4CCND1CCND3CDK6CCND2 | |
| SCHEMBL19294159 | 0.73 | CDK4 (0.64) | CDK4CCND1CCND3CDK6CCND2 | |
| SCHEMBL23913121 | 0.73 | CDK4 (0.61) | CDK4CCND1CCND3CDK6CCND2 | |
| SCHEMBL28404189 | 0.72 | CDK4 (0.63) | CDK4CCND1CCND3CDK6CCND2 | |
| SCHEMBL18788069 | 0.71 | CDK4 (0.62) | CDK4CCND1CCND3CDK6CCND2 | |
| SCHEMBL4833350 | 0.71 | CDK4 (0.62) | CDK4CCND1CCND3CDK6CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021110122-A1 | COMBINATION THERAPY OF CDK4/6 INHIBITOR | 基石药业（苏州）有限公司 | 2021-06-10 | — | — | WO | disclosed |
| US-10676474-B2 | 1,6-naphthyridine derivatives as CDK4/6 inhibitor | CSTONE PHARMACEUTICALS (KY) | 2020-06-09 | — | — | US | disclosed |
| US-20190315745-A1 | CDK4/6 INHIBITOR | CSTONE PHARMACEUTICALS (KY) | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315745-A1 | CDK4/6 INHIBITOR | CDK4, CDK6, CDK2 | MEN1 2378/4885ALDH1A1 1082/4885KMT2A 694/4885 |
| US-10676474-B2 | 1,6-naphthyridine derivatives as CDK4/6 inhibitor | CDK4, CDK6, CDK9 | MEN1 1950/4885ALDH1A1 696/4885KMT2A 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.