Sugi Predict

Sugi Predict / Compounds / SCHEMBL21484597

SCHEMBL21484597

SCHEMBL21484597

N#C/C(=C\c1ccc(O)c(O)c1)C(=O)Nc1nc(-c2ncccc2F)cs1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 7/20 0.53
▸ KMT2A Q03164 7/20 0.53
▸ BLM P54132 5/20 0.53
▸ POLB P06746 2/20 0.53
▸ USP2 O75604 1/20 0.53
▸ NSD2 O96028 1/20 0.53
▸ ALPL P05186 1/20 0.53
▸ ALPI P09923 1/20 0.53
▸ ALPG P10696 1/20 0.53
▸ APOBEC3G Q9HC16 1/20 0.53
▸ SAE1 Q9UBE0 1/20 0.53
▸ UBA2 Q9UBT2 1/20 0.53
▸ EGFR P00533 9/20 0.50
▸ ERBB2 P04626 6/20 0.50
▸ KDM4E B2RXH2 4/20 0.50
▸ TP53 P04637 4/20 0.50
▸ CYP3A4 P08684 4/20 0.50
▸ MAPT P10636 4/20 0.50
▸ ALOX15 P16050 4/20 0.50
▸ ALOX12 P18054 4/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21484885 0.89 EGFR (0.60) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21484853 0.87 MEN1 (0.57) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21505948 0.87 FTO (0.43) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21495019 0.87 CSNK2A1 (0.44) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21505880 0.87 FTO (0.43) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21484598 0.85 MRE11 (0.57) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21484831 0.84 EGFR (0.52) MEN1KMT2ABLMPOLBEGFR
SCHEMBL21484881 0.83 EGFR (0.53) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21484889 0.82 EGFR (0.54) MEN1KMT2ABLMPOLBUSP2
SCHEMBL21484629 0.82 EGFR (0.62) MEN1KMT2ABLMPOLBEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11453663-B2 Substituted propanamides as inhibitors of nucleases MASARYKOVA UNIVERZITA (CZ) 2022-09-27 — — US disclosed
US-20220073507-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2022-03-10 — — US disclosed
CN-112351983-A Substituted propionamides as inhibitors of nucleases 马萨里克大学 2021-02-09 — — CN disclosed
EP-3556756-B1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2020-10-07 — — EP disclosed
EP-3556756-B1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2020-10-07 — — EP disclosed
WO-2019201867-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2019-10-24 — — WO disclosed
EP-3556756-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES Masarykova univerzita (CZ) 2019-10-23 — — EP disclosed
EP-3556756-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES Masarykova univerzita (CZ) 2019-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220073507-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES DNASE1, RNASEH1, FEN1 MEN1 1573/4885KMT2A 1049/4885BLM 398/4885
US-11453663-B2 Substituted propanamides as inhibitors of nucleases DNASE1, RNASEH1, FEN1 MEN1 1573/4885KMT2A 1049/4885BLM 398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.