Sugi Predict

Sugi Predict / Compounds / SCHEMBL21484718

SCHEMBL21484718

SCHEMBL21484718

CC(=O)Nc1ccc(/C=C(\C#N)C(=O)Nc2nc(-c3ccccc3)cs2)cc1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 10/20 0.59
▸ MEN1 O00255 8/20 0.59
▸ MAPT P10636 6/20 0.59
▸ ALDH1A1 P00352 6/20 0.59
▸ LMNA P02545 4/20 0.59
▸ SMN1; SMN2 Q16637 3/20 0.59
▸ MAPK1 P28482 2/20 0.59
▸ HTT P42858 1/20 0.59
▸ HPGD P15428 1/20 0.56
▸ GAA P10253 4/20 0.53
▸ RAB9A P51151 4/20 0.53
▸ PKM P14618 1/20 0.53
▸ L3MBTL1 Q9Y468 1/20 0.53
▸ KDM4E B2RXH2 3/20 0.52
▸ NPC1 O15118 3/20 0.52
▸ POLB P06746 1/20 0.52
▸ ADORA3 P0DMS8 1/20 0.51
▸ GFER P55789 1/20 0.51
▸ TDP1 Q9NUW8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21484899 0.89 MAPT (0.53) KMT2AMEN1MAPTALDH1A1LMNA
SCHEMBL21484901 0.89 MAPT (0.53) KMT2AMEN1MAPTALDH1A1LMNA
SCHEMBL28511010 0.88 MAPT (0.55) KMT2AMEN1MAPTALDH1A1LMNA
SCHEMBL28511011 0.88 MAPT (0.55) KMT2AMEN1MAPTALDH1A1LMNA
SCHEMBL21484829 0.87 CSNK2A1 (0.55) KMT2AMEN1MAPTLMNASMN1; SMN2
SCHEMBL21484826 0.87 CSNK2A1 (0.55) KMT2AMEN1MAPTLMNASMN1; SMN2
SCHEMBL21484841 0.86 EGFR (0.48) KMT2AMEN1MAPTALDH1A1LMNA
SCHEMBL21495011 0.83 MAPT (0.59) KMT2AMEN1MAPTALDH1A1LMNA
SCHEMBL21484838 0.83 MAPT (0.59) KMT2AMEN1MAPTALDH1A1LMNA
SCHEMBL21484629 0.83 EGFR (0.62) KMT2AMEN1MAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11453663-B2 Substituted propanamides as inhibitors of nucleases MASARYKOVA UNIVERZITA (CZ) 2022-09-27 — — US disclosed
US-20220073507-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2022-03-10 — — US disclosed
CN-112351983-A Substituted propionamides as inhibitors of nucleases 马萨里克大学 2021-02-09 — — CN disclosed
EP-3556756-B1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2020-10-07 — — EP disclosed
EP-3556756-B1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES UNIV MASARYKOVA (CZ) 2020-10-07 — — EP disclosed
WO-2019201867-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES MASARYKOVA UNIVERZITA (CZ) 2019-10-24 — — WO disclosed
EP-3556756-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES Masarykova univerzita (CZ) 2019-10-23 — — EP disclosed
EP-3556756-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES Masarykova univerzita (CZ) 2019-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220073507-A1 SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES DNASE1, RNASEH1, FEN1 KMT2A 1049/4885MEN1 1573/4885MAPT 1351/4885
US-11453663-B2 Substituted propanamides as inhibitors of nucleases DNASE1, RNASEH1, FEN1 KMT2A 1049/4885MEN1 1573/4885MAPT 1351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.