Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.75 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.75 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.73 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.58 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.58 |
| ▸ | KDM5C | P41229 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | KDM6B | O15054 | 3/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL1921951 | 1.00 | EGLN1 (0.75) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL16415716 | 1.00 | EGLN1 (0.75) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL35204 | 1.00 | EGLN1 (0.75) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL2305765 | 0.96 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL16395683 | 0.96 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL16395681 | 0.96 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL15861411 | 0.96 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL7590095 | 0.96 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL10776609 | 0.96 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL28276727 | 0.96 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1SLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519491-A2 | PURIFICATION OF SUCCINIC ACID FROM THE FERMENTATION BROTH CONTAINING AMMONIUM SUCCINATE | Myriant Corporation (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082378-A2 | PURIFICATION OF SUCCINIC ACID FROM THE FERMENTATION BROTH CONTAINING AMMONIUM SUCCINATE | MYRIANT TECHNOLOGIES LLC (US) | 2011-07-07 | — | — | WO | disclosed |
| EP-0850049-A1 | COMPOSITION FOR PH DEPENDENT CONTROLLED RELEASE OF ACTIVE INGREDIENTS AND METHODS FOR PRODUCING IT | Oy Polymer Corex Kuopio Ltd. (FI) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997002018-A1 | COMPOSITION FOR PH DEPENDENT CONTROLLED RELEASE OF ACTIVE INGREDIENTS AND METHODS FOR PRODUCING IT | OY POLYMER COREX KUOPIO LTD (FI) | 1997-01-23 | — | — | WO | disclosed |