Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 14/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 5/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | STK25 | O00506 | 1/20 | 0.41 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2149056 | 0.83 | AURKB (0.44) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2148756 | 0.82 | AURKB (0.46) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2948567 | 0.81 | AURKB (0.64) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2146309 | 0.80 | AURKB (0.55) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2169729 | 0.77 | AURKB (0.65) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2161109 | 0.76 | AURKB (0.56) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2148867 | 0.74 | AURKA (0.47) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2160263 | 0.74 | AURKB (0.68) | AURKAAURKBAURKCSRCGSK3B | |
| SCHEMBL2148590 | 0.74 | AURKA (0.55) | AURKAAURKBAURKC | |
| SCHEMBL2150067 | 0.74 | AURKB (0.56) | AURKAAURKBAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |