Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 19/20 | 0.44 |
| ▸ | AURKA | O14965 | 17/20 | 0.44 |
| ▸ | AURKC | Q9UQB9 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148756 | 0.91 | AURKB (0.46) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2148563 | 0.83 | CYP1A2 (0.47) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2948567 | 0.82 | AURKB (0.64) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2146309 | 0.81 | AURKB (0.55) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2169729 | 0.78 | AURKB (0.65) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2161109 | 0.76 | AURKB (0.56) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2175840 | 0.76 | AURKB (0.46) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2148867 | 0.76 | AURKA (0.47) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2160263 | 0.75 | AURKB (0.68) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2148590 | 0.73 | AURKA (0.55) | AURKBAURKAAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | claimed |
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |