Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 20/20 | 0.58 |
| ▸ | AURKA | O14965 | 19/20 | 0.58 |
| ▸ | AURKC | Q9UQB9 | 4/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148750 | 0.91 | AURKA (0.70) | AURKBAURKAAURKC | |
| SCHEMBL2226895 | 0.91 | AURKA (0.70) | AURKBAURKAAURKC | |
| SCHEMBL2149892 | 0.90 | AURKA (0.61) | AURKBAURKAAURKC | |
| SCHEMBL2183054 | 0.89 | AURKB (0.58) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2146695 | 0.89 | AURKB (0.58) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2161764 | 0.87 | AURKB (0.57) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2149372 | 0.86 | AURKB (0.48) | AURKBAURKASRCGSK3B | |
| SCHEMBL2146188 | 0.85 | AURKB (0.51) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2148571 | 0.84 | AURKB (0.48) | AURKBAURKAAURKCSRCGSK3B | |
| SCHEMBL2165141 | 0.79 | AURKA (0.71) | AURKBAURKAAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | claimed |
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |