Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 17/20 | 0.51 |
| ▸ | SRC | P12931 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 13/20 | 0.46 |
| ▸ | AURKC | Q9UQB9 | 5/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148571 | 0.97 | AURKB (0.48) | AURKBSRCGSK3BAURKAAURKC | |
| SCHEMBL2146309 | 0.87 | AURKB (0.55) | AURKBSRCGSK3BAURKAAURKC | |
| SCHEMBL2148602 | 0.85 | AURKB (0.58) | AURKBSRCGSK3BAURKAAURKC | |
| SCHEMBL2149372 | 0.85 | AURKB (0.48) | AURKBSRCGSK3BAURKA | |
| SCHEMBL2148687 | 0.85 | AURKB (0.41) | AURKBSRCGSK3BAURKAAURKC | |
| SCHEMBL2148465 | 0.85 | AURKB (0.43) | AURKBSRCGSK3BAURKAAURKC | |
| SCHEMBL2183054 | 0.84 | AURKB (0.58) | AURKBSRCGSK3BAURKAAURKC | |
| SCHEMBL2146695 | 0.84 | AURKB (0.58) | AURKBSRCGSK3BAURKAAURKC | |
| SCHEMBL2153217 | 0.84 | SRC (0.44) | AURKBSRCGSK3BAURKACCNE2 | |
| SCHEMBL2148475 | 0.82 | NPC1 (0.43) | AURKBSRCGSK3BAURKAAURKC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |