Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | BCHE | P06276 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20381996 | 0.92 | SMN1; SMN2 (0.51) | TSHRBCHEKDM4EGAACYP2C9 | |
| SCHEMBL26999697 | 0.83 | BCHE (0.52) | TSHRBCHEKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL24777711 | 0.83 | BCHE (0.68) | TSHRBCHEKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL8820146 | 0.83 | BCHE (0.52) | TSHRBCHEKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL441659 | 0.82 | BCHE (0.69) | TSHRBCHEKDM4ECYP2C9SMN1; SMN2 | |
| SCHEMBL3461210 | 0.82 | BCHE (0.51) | BCHEKDM4EGAASMN1; SMN2KDM2B | |
| SCHEMBL20962701 | 0.81 | SMN1; SMN2 (0.58) | TSHRGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25570176 | 0.79 | BCHE (0.49) | TSHRBCHEKDM4EGAAMEN1 | |
| SCHEMBL25570904 | 0.79 | BCHE (0.49) | TSHRBCHEKDM4EGAAMEN1 | |
| SCHEMBL3315913 | 0.78 | TSHR (0.62) | TSHRBCHEKDM4EGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315724-A1 | PYRAZOLO AND TRIAZOLO BICYCLIC COMPOUNDS AS JAK KINASE INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315724-A1 | PYRAZOLO AND TRIAZOLO BICYCLIC COMPOUNDS AS JAK KINASE INHIBITORS | JAK3, JAK1, JAK2 | TSHR 2126/4885BCHE 4720/4885KDM4E 1554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.