Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102181 | 0.87 | BCHE (0.79) | BCHEKDM4EKDM2B | |
| SCHEMBL24777711 | 0.85 | BCHE (0.68) | BCHEKDM4EALDH1A1SMN1; SMN2KDM2B | |
| SCHEMBL8820146 | 0.85 | BCHE (0.52) | BCHEKDM4ESMN1; SMN2KDM2BTSHR | |
| SCHEMBL26999697 | 0.85 | BCHE (0.52) | BCHEKDM4ESMN1; SMN2KDM2BTSHR | |
| SCHEMBL3461210 | 0.83 | BCHE (0.51) | BCHEKDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL21486158 | 0.82 | TSHR (0.57) | BCHEKDM4ESMN1; SMN2KDM2BTSHR | |
| SCHEMBL13999836 | 0.81 | BCHE (0.62) | BCHEKDM4EALDH1A1MAPK1MAPT | |
| Bromide SCHEMBL10779785 | 0.81 | BCHE (0.97) | BCHEKDM4EKDM2B | |
| SCHEMBL3936335 | 0.81 | BCHE (0.67) | BCHEALDH1A1MAPK1SMN1; SMN2KDM2B | |
| SCHEMBL15998502 | 0.81 | BCHE (0.67) | BCHEALDH1A1MAPK1SMN1; SMN2KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506176-B1 | AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2013-04-24 | — | — | EP | claimed |
| EP-1831206-B1 | N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS AND COMBINATORIAL BENZIMIDAZOLE LIBRARY | OSI PHARM INC (US) | 2011-08-24 | — | — | EP | claimed |
| US-20060116402-A1 | N-substituted benzimidazolyl c-Kit inhibitors and combinatorial benzimidazole library | OSI PHARMACEUTICALS, INC. | 2006-06-01 | — | — | US | claimed |
| US-6429282-B1 | MIXING PRIMARY AND SECONDARY AMINES WITH EMERALDINE BASE POLYANILINE; STORAGE STABILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-08-06 | — | — | US | claimed |
| WO-2002042361-A1 | STABLE, CONCENTRATED SOLUTIONS OF POLYANILINE USING AMINES AS GEL INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-05-30 | — | — | WO | claimed |
| US-11420973-B2 | Amide substituted indole compounds useful as TLR inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3728221-B1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | disclosed |
| EP-3507284-B1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-05-25 | — | — | EP | disclosed |
| US-20200331920-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | PROTIX B.V. (NL) | 2020-10-22 | — | — | US | disclosed |
| EP-3507284-A1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | Bristol-Myers Squibb Company (US) | 2019-07-10 | — | — | EP | disclosed |
| US-10144706-B2 | Compounds useful as immunomodulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-12-04 | — | — | US | disclosed |
| WO-2018044963-A1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-08 | — | — | WO | disclosed |
| US-5942387-A | Combinatorial process for preparing substituted thiophene libraries | ELI LILLY AND COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0825164-A2 | Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |
| EP-0816309-A1 | Scavenger assisted combinatorial process for preparing libraries of urea and thiourea compounds | ELI LILLY AND COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0816310-A2 | Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds | ELI LILLY AND COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5382590-A | Gastrointestinal disorders and nervous system disorders | RHONE-POULENC RORER S.A. (FR) | 1995-01-17 | — | — | US | disclosed |
| EP-0190709-B1 | BENZOXAZINORIFAMYCIN DERIVATIVE, PROCESS FOR PREPARING THE SAME AND ANTI-BACTERIAL AGENT CONTAINING THE SAME | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-12-06 | — | — | EP | disclosed |
| US-4690919-A | Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-09-01 | — | — | US | disclosed |
| EP-0190709-A1 | Benzoxazinorifamycin derivative, process for preparing the same and anti-bacterial agent containing the same | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1986-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11420973-B2 | Amide substituted indole compounds useful as TLR inhibitors | TLR9, TLR1, TLR7 | BCHE 4871/4885KDM4E 2741/4885ALDH1A1 3363/4885 |
| US-10144706-B2 | Compounds useful as immunomodulators | CD74, HLA-DRB1, CD47 | BCHE 1249/4885KDM4E 4249/4885ALDH1A1 1130/4885 |
| US-20200331920-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | TLR9, TLR1, TLR7 | BCHE 4816/4885KDM4E 2326/4885ALDH1A1 3748/4885 |
| US-20060116402-A1 | N-substituted benzimidazolyl c-Kit inhibitors and combinatorial benzimidazole library | KIT, CHUK, TNNI3K | BCHE 988/4885KDM4E 1478/4885ALDH1A1 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.