Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505416 | 0.78 | ALDH1A1 (0.50) | LPAR1LPAR5DHODHPARP10POLB | |
| SCHEMBL21483129 | 0.76 | TLR4 (0.65) | TLR4TLR2 | |
| SCHEMBL15515736 | 0.75 | ALDH1A1 (0.54) | LPAR1LPAR5POLBHSP90AA1MAPT | |
| SCHEMBL21486338 | 0.71 | TEAD4 (0.45) | NFE2L2LPAR1LPAR5HTR1ASLC6A2 | |
| SCHEMBL17423587 | 0.71 | MAPT (0.45) | LPAR1LPAR5HTR1ASLC6A2SLC6A4 | |
| SCHEMBL13861391 | 0.71 | LPAR1 (0.40) | LPAR1LPAR5HTR1ASLC6A2SLC6A4 | |
| SCHEMBL1129355 | 0.71 | MAPT (0.45) | LPAR1LPAR5HTR1ASLC6A2SLC6A4 | |
| SCHEMBL5539624 | 0.71 | LPAR1 (0.40) | LPAR1LPAR5HTR1ASLC6A2SLC6A4 | |
| SCHEMBL23170416 | 0.70 | HSD17B10 (0.41) | LPAR1LPAR5HTR1ASLC6A2SLC6A4 | |
| SCHEMBL16415975 | 0.68 | SLC6A2 (0.45) | NFE2L2LPAR1LPAR5HTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019196915-A1 | METHOD FOR PREPARING PYRROLOAMINOPYRIDAZINONE COMPOUND AND INTERMEDIATES THEREOF | 江苏恒瑞医药股份有限公司 | 2019-10-17 | — | — | WO | disclosed |