Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 16/20 | 0.46 |
| ▸ | CDK2 | P24941 | 8/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.42 |
| ▸ | CCNH | P51946 | 7/20 | 0.42 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.42 |
| ▸ | CDK4 | P11802 | 4/20 | 0.42 |
| ▸ | CDK9 | P50750 | 4/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.42 |
| ▸ | CDK8 | P49336 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | INSRR | P14616 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29899423 | 0.84 | CDK7 (0.48) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL23530960 | 0.84 | CDK7 (0.48) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL21486447 | 0.82 | CDK7 (0.42) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL30209116 | 0.81 | CDK7 (0.51) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL24962532 | 0.81 | CDK7 (0.51) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL1368924 | 0.80 | CDK7 (0.67) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL23382171 | 0.79 | CDK7 (0.51) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL23381954 | 0.79 | CDK7 (0.55) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL23381632 | 0.79 | CDK9 (0.42) | CDK7CDK2CCNE1CCNHCDK1 | |
| SCHEMBL24963424 | 0.79 | CDK2 (0.53) | CDK7CDK2CCNE1CCNHCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | LEAD DISCOVERY CENTER GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| WO-2019197549-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | QURIENT CO., LTD. (KR) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147427-A1 | PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE | CDK1, CDK2, CDK15 | CDK7 14/4885CDK2 2/4885CCNE1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.