Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.65 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.62 |
| ▸ | MC4R | P32245 | 2/20 | 0.55 |
| ▸ | MC3R | P41968 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19710653 | 1.00 | HPGD (0.69) | HPGDHTTRECQLSIGMAR1NPY5R | |
| SCHEMBL23575950 | 0.89 | HPGD (0.75) | HPGDHTTRECQLSIGMAR1NPY5R | |
| SCHEMBL19710020 | 0.89 | HPGD (0.75) | HPGDHTTRECQLSIGMAR1NPY5R | |
| SCHEMBL14261162 | 0.82 | HPGD (0.61) | HPGDHTTRECQLSIGMAR1NPY5R | |
| SCHEMBL19710205 | 0.81 | HPGD (0.48) | HPGDHTTRECQLSIGMAR1NPY5R | |
| SCHEMBL21489827 | 0.79 | RAB9A (0.59) | HPGDHTTRECQLNPC1RAB9A | |
| SCHEMBL19710504 | 0.79 | RAB9A (0.59) | HPGDHTTRECQLNPC1RAB9A | |
| SCHEMBL7240526 | 0.79 | SIGMAR1 (1.00) | SIGMAR1BCHEACHE | |
| SCHEMBL7849079 | 0.79 | HPGD (0.93) | HPGDHTTRECQLSIGMAR1MAPT | |
| SCHEMBL947150 | 0.78 | MAPT (0.73) | HPGDMAPTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | HPGD 3211/4885HTT 4016/4885RECQL 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.