Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3288949 | 0.98 | LMNA (0.59) | LMNAALDH1A1SRD5A2CES2CES1 | |
| Bicarbonate SCHEMBL15643478 | 0.93 | KMT2A (0.54) | LMNAALDH1A1SRD5A2CES2CES1 | |
| Benzophenone SCHEMBL3324674 | 0.93 | ALDH1A1 (0.58) | LMNAALDH1A1SRD5A2CES2CES1 | |
| Formic Acid SCHEMBL2149150 | 0.92 | ALDH1A1 (0.52) | LMNAALDH1A1SRD5A2CES2CES1 | |
| SCHEMBL50648 | 0.91 | KMT2A (0.56) | LMNAALDH1A1SRD5A2CES2CES1 | |
| Lithium SCHEMBL30994890 | 0.89 | KMT2A (0.54) | LMNAALDH1A1SRD5A2CES2CES1 | |
| SCHEMBL31220878 | 0.89 | KMT2A (0.54) | LMNAALDH1A1SRD5A2CES2CES1 | |
| SCHEMBL28867988 | 0.89 | KMT2A (0.54) | LMNAALDH1A1SRD5A2CES2CES1 | |
| SCHEMBL29227877 | 0.89 | KMT2A (0.54) | LMNAALDH1A1SRD5A2CES2CES1 | |
| SCHEMBL27640689 | 0.89 | KMT2A (0.54) | LMNAALDH1A1SRD5A2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342237-A1 | PHOTOINITIATOR MIXTURES | BASF SE (DE) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010060702-A1 | PHOTOINITIATOR MIXTURES | BASF SE (DE) | 2010-06-03 | — | — | WO | disclosed |