Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14705129 | 1.00 | HTT (0.55) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL5964493 | 0.96 | POLB (0.54) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL1012270 | 0.93 | POLB (0.52) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL28400061 | 0.93 | POLB (0.52) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL1011872 | 0.93 | POLB (0.52) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL14418100 | 0.93 | HTT (0.55) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL25039321 | 0.92 | POLB (0.51) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL5962896 | 0.92 | POLB (0.51) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL25040483 | 0.92 | POLB (0.51) | HTTPOLBNPC1CYP3A4PKM | |
| SCHEMBL4372581 | 0.92 | POLB (0.51) | HTTPOLBNPC1CYP3A4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11779650-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-10-10 | — | — | US | disclosed |
| US-11771775-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-10-03 | — | — | US | disclosed |
| US-11690918-B2 | Pyrrolobenzodiazepine-anti-CD22 antibody conjugates | MEDIMMUNE LIMITED (GB) | 2023-07-04 | — | — | US | disclosed |
| US-20230143309-A1 | PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES | MEDIMMUNE LIMITED (GB) | 2023-05-11 | — | — | US | disclosed |
| US-11517626-B2 | Pyrrolobenzodiazepine antibody conjugates | MEDIMMUNE LIMITED (GB) | 2022-12-06 | — | — | US | disclosed |
| US-20210187117-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LIMITED (GB) | 2021-06-24 | — | — | US | disclosed |
| EP-3525830-B1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LTD (GB) | 2021-03-10 | — | — | EP | disclosed |
| US-20200405880-A1 | PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES | BLUE OWL OPPORTUNISTIC MASTER FUND I, L.P. (FORMERLY KNOWN AS OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P.) | 2020-12-31 | — | — | US | disclosed |
| EP-3470086-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| US-20200345861-A1 | PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES | BLUE OWL OPPORTUNISTIC MASTER FUND I, L.P. (FORMERLY KNOWN AS OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P.) | 2020-11-05 | — | — | US | disclosed |
| EP-2318413-B1 | PYRROLOBENZODIAZEPINES | SPIROGEN LTD (GB) | 2012-05-09 | — | — | EP | disclosed |
| US-20110201803-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| EP-1675857-B1 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | US GOV HEALTH & HUMAN SERV (US) | 2011-07-13 | — | — | EP | disclosed |
| US-7834005-B2 | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-11-16 | — | — | US | disclosed |
| WO-2010043877-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010010347-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2010-01-28 | — | — | WO | disclosed |
| US-20090149449-A1 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICE (US) | 2009-06-11 | — | — | US | disclosed |
| US-7511032-B2 | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-03-31 | — | — | US | disclosed |
| EP-1675857-A2 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005040170-A2 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200345861-A1 | PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES | CD79B, BCL6B, BCL6 | HTT 1998/4885POLB 1824/4885NPC1 3743/4885 |
| US-11690918-B2 | Pyrrolobenzodiazepine-anti-CD22 antibody conjugates | CD22, CD2, CD2BP2 | HTT 2707/4885POLB 2577/4885NPC1 3812/4885 |
| US-11779650-B2 | Pyrrolobenzodiazepine-antibody conjugates | IL2RA, CD4, IL2 | HTT 2331/4885POLB 2900/4885NPC1 4493/4885 |
| US-20090149449-A1 | PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO | CCNB1, NPY1R, CCNO | HTT 3569/4885POLB 1300/4885NPC1 627/4885 |
| US-11771775-B2 | Pyrrolobenzodiazepine-antibody conjugates | CD79B, BCL6B, BCL6 | HTT 1998/4885POLB 1824/4885NPC1 3743/4885 |
| US-20110201803-A1 | PYRROLOBENZODIAZEPINES | HCRTR2, HCRTR1, CBR3 | HTT 637/4885POLB 1637/4885NPC1 3213/4885 |
| US-20230143309-A1 | PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES | CD79B, H1-10, DRD1 | HTT 3365/4885POLB 1167/4885NPC1 3253/4885 |
| US-20200405880-A1 | PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES | IL2RA, CD4, IL2 | HTT 2331/4885POLB 2900/4885NPC1 4493/4885 |
| US-11517626-B2 | Pyrrolobenzodiazepine antibody conjugates | CD79B, DRD1, H1-10 | HTT 3680/4885POLB 1360/4885NPC1 3121/4885 |
| US-20210187117-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | H1-10, DRD1, DRD2 | HTT 2094/4885POLB 1739/4885NPC1 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.