Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TYR | P14679 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26122412 | 0.90 | MRE11 (0.53) | NPC1KDM4EHSD17B10MAPK1ABL1 | |
| SCHEMBL30313761 | 0.84 | NPC1 (0.58) | NPC1KDM4EHSD17B10MAPK1ABL1 | |
| SCHEMBL21484645 | 0.80 | ABL1 (0.57) | NPC1KDM4EMAPK1ABL1RAB9A | |
| SCHEMBL26122183 | 0.80 | CCR1 (0.55) | NPC1KDM4ERAB9AMAPTMEN1 | |
| SCHEMBL17716927 | 0.79 | ALDH1A1 (0.75) | NPC1KDM4EHSD17B10MAPK1RAB9A | |
| SCHEMBL30772147 | 0.77 | ABL1 (0.76) | NPC1KDM4EHSD17B10MAPK1ABL1 | |
| SCHEMBL2020280 | 0.77 | ABL1 (0.73) | NPC1KDM4EHSD17B10MAPK1ABL1 | |
| SCHEMBL22305595 | 0.76 | MAPK1 (0.51) | NPC1KDM4EMAPK1RAB9AMAPT | |
| SCHEMBL28200307 | 0.76 | ABL1 (0.76) | NPC1KDM4EHSD17B10MAPK1ABL1 | |
| SCHEMBL19994395 | 0.76 | MAPT (0.66) | NPC1KDM4EHSD17B10RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019201867-A1 | SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |