Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.85 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22932159 | 0.92 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL22932164 | 0.87 | CRBN (0.79) | CRBNDDB1ACP1 | |
| SCHEMBL22932498 | 0.87 | CRBN (1.00) | CRBN | |
| SCHEMBL21496428 | 0.85 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL22932171 | 0.85 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL31391103 | 0.81 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL22932129 | 0.81 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL21496464 | 0.79 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL558348 | 0.77 | LMNA (0.73) | CRBNLMNAMAPK1ACP1 | |
| SCHEMBL21496426 | 0.75 | CRBN (0.85) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781156-A1 | SPIROCYCLIC COMPOUNDS | C4 Therapeutics, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204354-A1 | SPIROCYCLIC COMPOUNDS | C4 THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |