Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 10/20 | 0.47 |
| ▸ | BCR | P11274 | 10/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501823 | 0.77 | TRPA1 (0.53) | KCNH2SCN5ASCN9AABL1BCR | |
| SCHEMBL28403016 | 0.77 | TRPA1 (0.53) | KCNH2SCN5ASCN9AABL1BCR | |
| SCHEMBL20267695 | 0.76 | KCNH2 (0.49) | KCNH2SCN5ASCN9AABL1BCR | |
| SCHEMBL21497143 | 0.74 | CTSC (0.48) | KCNH2SCN5ASCN9AABL1BCR | |
| SCHEMBL1923201 | 0.74 | MAPT (0.61) | KCNH2SCN5ASCN9AABL1BCR | |
| SCHEMBL3194551 | 0.74 | MAPT (0.61) | KCNH2SCN5ASCN9AABL1BCR | |
| SCHEMBL1702887 | 0.74 | PDGFRB (0.62) | KCNH2SCN5ASCN9AABL1BCR | |
| SCHEMBL31220867 | 0.72 | DHODH (0.53) | ABL1BCRCTSCNPC1RAB9A | |
| SCHEMBL3399556 | 0.71 | ABL1 (0.78) | ABL1BCR | |
| SCHEMBL12614300 | 0.71 | MAPT (0.54) | ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781165-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | Virginia Tech Intellectual Properties, Inc. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | claimed |